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Tomato bushy stunt virus
Tomato bushy stunt virus is a tombusvirus first reported in tomatoes in 1935. Depending upon the host, TBSV causes stunting of growth, leaf mottling, and deformed or absent fruit. The virus is transmitted manually through the use of contaminated cutting tools. A wide variety of species are affected.
The virus is a spherical virus with a triangulation number of ''T'' = 3, hence it has 180 subunits of capsid protein. In 1978, its structure was determined by x-ray crystallography by Stephen C. Harrison.
The genome of TBSV is a single-stranded positive-sense RNA of ~4800 nucleotides. The virus encodes 5 genes, to express a replicase composed of two proteins (P33 and P92), a capsid protein (CP) of 42 kilodaltons, as well as p19 and P22. The P22 protein is primarily associated with cell to cell movement. The p19 protein is a pathogenicity factor and functions by suppressing the RNA silencing pathway. p19 binds viral derived short-interfering RNAs and prevents their incorporation into the RNA-induced Silencing Complex (RISC), thereby allowing viral propagation in the host plant. 〔http://www.ncbi.nlm.nih.gov/pubmed/7491767〕
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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